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2,4-Dicloro actophenone

2',4'-Dichloroacetophenone

CAS: 2234-16-4

Molecular Formula: C8H6Cl2O

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2,4-Dicloro actophenone - Names and Identifiers

Name 2',4'-Dichloroacetophenone
Synonyms 2',4'-Dichloroacetop
2,4-Dicloro actophenone
Ketoconazole Impurity 5
2,4-Dichloracetophenone
2',4'-Dichloroacetophenone
1-(2,4-dichlorophenyl)-ethanon
Methyl 2,4-dichlorophenyl ketone
CAS 2234-16-4
EINECS 218-780-8
InChIKey XMCRWEBERCXJCH-UHFFFAOYSA-N

2,4-Dicloro actophenone - Physico-chemical Properties

Molecular FormulaC8H6Cl2O
Molar Mass189.04
Density1.304g/cm3
Melting Point29-34℃
Boling Point246.7°C at 760 mmHg
Flash Point100.9°C
Water Solubilityca. 200 mg/L
Vapor Presure0.0268mmHg at 25°C
AppearanceForm Solid, color Colorless to yellow-brown
Storage ConditionSealed in dry,Room Temperature
Refractive Index1.548
MDLMFCD00000581
Physical and Chemical PropertiesDensity 1.32
melting point 29-34°C
boiling point 242°C
refractive index 1.5635
flash point 131°C
water-soluble ca. 200 mg/L
UseUsed as a pharmaceutical intermediate for the synthesis of ketoconazole drugs

2,4-Dicloro actophenone - Risk and Safety

Hazard SymbolsXn - Harmful
Harmful
Risk CodesR22 - Harmful if swallowed
R52/53 - Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment. 
Safety DescriptionS61 - Avoid release to the environment. Refer to special instructions / safety data sheets. 
WGK Germany2
TSCAYes
HS Code29143990

2,4-Dicloro actophenone - Upstream Downstream Industry

Raw MaterialsDichloromethane
Aluminum chloride
Acetyl chloride
1,3-Dichlorobenzene
Downstream ProductsItraconazole
2,2,2',4'-TETRACHLOROACETOPHENONE
1-(2,4-DICHLORO-PHENYL)-ETHYLAMINE
2,2',4'-Trichloroacetophenone

2,4-Dicloro actophenone - Nature

storage conditions Sealed in dry,Room Temperature
morphology Solid
color Colorless to yellow-brown
water solubility ca. 200 mg/L
BRN 637819
InChIKey XMCRWEBERCXJCH-UHFFFAOYSA-N
NIST chemical information Ethanone, 1-(2,4-dichlorophenyl)-(2234-16-4)
EPA chemical information 2',4'-Dichloroacetophenone (2234-16-4)
Last Update：2024-04-10 22:29:15

2,4-Dicloro actophenone - Security information

WGK Germany 2
Hazard Note Irritant
TSCA Yes
customs code 29143990
Last Update：2024-04-10 22:29:15

2,4-Dicloro actophenone - Uses and synthesis methods

Chemical properties

2,4-dichloroacetophenone is white crystal, m.p.33 ~ 34 ℃, B. p.128 ~ 131 ℃/2.4kpa,n20D 1.5635, insoluble in water, soluble in benzene, toluene, alcohol and other organic solvents.

Uses

1,2, 4-dichloroacetophenone is the raw material for preparing & omega;-bromo -2,4-dichloroacetophenone or & omega;-2,4-trichloroacetophenone, the latter two It is an intermediate for the preparation of fungicides such as imazazole, propiconazole, and acyclazole, as well as an intermediate for insecticide poison and her.

2. Used as a pharmaceutical intermediate for the synthesis of ketoconazole drugs

3. Intermediate of ketoconazole.

Production method

The preparation method is to add m-dichlorobenzene into the reaction bottle, raise the temperature to 50 ℃, add an appropriate amount of anhydrous aluminum trichloride under stirring, keep the temperature at 50 ℃, add acetyl chloride dropwise, gradually raise the temperature to 100 ℃ after dropping, and stir at this temperature for 8h. After the reaction is over, add dichloromethane into the reaction solution and pour it into water, place, the organic layer was washed with water, dried, evaporated to the solvent and distilled under reduced pressure, and the fraction of 160~180 ℃/0.015 MPa was collected to obtain a white crystal of 2,4-dichloroacetophenone.

Last Update：2024-04-09 18:58:34
2,4-Dicloro actophenone
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Nantong Reform Petro-Chemical CO., LTD.
Spot supply
Product Name: 2',4'-Dichloroacetophenone Request for quotation
CAS: 2234-16-4
Tel: +86-17551318830
Email: r@reformchem.com­
Mobile: +86-17551318830
QQ: 3785839865 Click to send a QQ messageSend QQ message
Jiangsu Pules Biotechnology Co.,Ltd.
Product Name: 2',4'-Dichloroacetophenone Request for quotation
CAS: 2234-16-4
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: 2',4'-Dichloroacetophenone Request for quotation
CAS: 2234-16-4
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 0086 189 4982 3763
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Shanghai Yuanye Bio-Technology Co., Ltd.
Spot supply
Product Name: 2',4'-Dichloroacetophenone Visit Supplier Webpage Request for quotation
CAS: 2234-16-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
Shanghai Worldyang Chemical Co.,Ltd.
Product Name: 2,4-Dichloroacetophenone Request for quotation
CAS: 2234-16-4
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228 Click to send a QQ message
Wechat: 13651600618
WhatsApp: +8613651600618
Hangzhou Verychem Science And Technology Co.Ltd
Product Name: 2,4-Dichloroacetophenone Request for quotation
CAS: 2234-16-4
Tel: +86-571-88162785
Email: Lucy@verypharm.com
Mobile: +86-13606544505
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View History
2,4-Dicloro actophenone
Raw Materials for 2,4-Dicloro actophenone
Dichloromethane
Aluminum chloride
Acetyl chloride
1,3-Dichlorobenzene
Downstream Products for 2,4-Dicloro actophenone
Itraconazole
2,2,2',4'-TETRACHLOROACETOPHENONE
1-(2,4-DICHLORO-PHENYL)-ETHYLAMINE
2,2',4'-Trichloroacetophenone
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